Hideo Iwasaki

Biologist and artist. Director of metaPhorest (biological art/ bioaesthetics platform), Professor, Department of Electrical Engineering and Bioscience, Waseda University. I am interested in the complicated relationship among scientific, philosophical, cultural, historical and aesthetic views of life. In 2007 I founded metaPhorest, an interdisciplinary art/science (bioaesthetics) platform, where both artists and biologists share space for science and art simultaneously. I have studied cyanobacterial circadian clock and morphogenesis, and is a co-founder of the Japanese synthetic biology society (Japanese Society for Cell Synthesis Research).

Group Exhibitions
"Nippon Fes" Kanagawa Pref. Library, Yokohama, 2021
"PREXTCE2020: Xplo-", ArtBunker B39, Bucheon, South Korea, 2020
"Japan Media Art Festival" Miraikan, Tokyo, 2019
“Conservation and restoration of the art” The university art museum, Tokyo University of the Arts, 2018
“Kenpoku Art 2016” Ibaraki, Japan, 2016
“Project Genesis” Ars Electronica Center, 2013-2015
“Materializing Exhibition II” The university art museum, Tokyo University of the Arts, 2014
“Bioaesthetics Open Lab: metaPhorest” (Open Space 2013), NTT InterCommunication Center, 2013-2014
“Biomedia Art (bioart.jp)” AkibaTamabi, Tokyo, 2013
“SCANZ2013: 3rd Nature” Puke Ariki, 2013
“4th State of Water/ from Micro to Macro) Torun Contemporary Art Museum, Poland, 2012
“BioAesthetics” Waseda University, 2012
“Utsurobune: Taro Okamoto 100th Anniversary” Taro Okamoto Museum, 2011
“Tokyo Designers Week 2011” Tokyo, 2011
“Austria Light Art Biennial” Linz, 2010
“Holland Paper Biennial” Den Haag, 2010
“Habana Biennial” Habana, 2009
“Spiral Independent Creators Festival” Tokyo, 2009
“Make Tokyo Meeting” Tokyo, 2009
“Science Agora 2009” Miraikan, 2009
“Spiral Independent Creators Festival” Tokyo, 2008
“Media Select” Nagoya University, 2004
“Toyota Triennial” Toyota City Museum, 2004

Solo Exhibition
“Culturing <Paper>cut” Gallerie Wünsch AirCube, Linz, 2013
“Metamorphorest: dialogue between paper and bacteria” Gallerie Wünsch AirCube, Linz, 2010

Articles related with arts/aesthetics (in English only)
Castro J.M., Iwasaki, H. “Fat as Soft Architecture: The Spontaneous Transformation of Lipids into Organic Microstructures with Predefined Biophysical Properties” Recent Advances in Natural Computing  July 2015 DOI: 10.1007/978-4-431-55105-8_8
Ishibashi T., Iwasaki H. (2015) “Breeding-Back of Goldfish as a Practice that Mediates Between Experimental Biology and Aesthetics” Recent Advances in Natural Computing July 2015 DOI: 10.1007/978-4-431-55105-8_9
Catts, O. & Iwasaki, H. (2014) “The Biogenic Timestamp” Synthetic Aesthetics: Investigating Synthetic Biology’s Designs on Nature”. (Eds D. Ginsburg et al.) MIT Press, pp. 195-204.

2019   Excellent Award, Art Division, 22nd Japan Media Art Festival
2011   Research Award, The Japanese Society for Genome Microbiology
2010   Selected member, Synthetic Aesthetics (NSF, BSCRC), with Oron Catts
2008   Outstanding Young Researcher Prize (Ministry of Education, Culture, Sports, Science and Technology)
2008   Howard Richter Prize (Spiral Independent Creators Festival)
2004   Sculpture Prize, the 1st Toyota Triennial (Toyota City Museum, Aichi)
2003   Research Award, The Japanese Society for Chronobiology
2001   Inoue Research Award for Young Scientist
CV as a biologist, August 2018
Ph.D., Biology, Nagoya University, October 1999
      Supervisor: Takao Kondo
      Thesis title: “Identification and functional analyses of circadian clock proteins in cyanobacteria”
M.A., Bioinformatics, Nagoya University, March 1997
      Supervisor: Tetsuo Ueda, Advisors: Takao Kondo, Dr. Masahiro Ishiura
      Thesis title: “Genetic and biochemical dissection of cyanobacterial clock” 
B.S., Agronomy, Nagoya University, March 1995
      Supervisor: Toshinobu Yaginuma, Advisors: Teruyuki Niimi, Okitsugu Yamashita
      Thesis title: “Identification and analysis of cdc2 homologue in Bombyx mori”

Positions Held
Professor, Waseda University, April 2012-present
PREST Researcher, JST, April 2007-March 2011
Associate Professor, Waseda University, April 2005-March 2012
Visiting Researcher, Biomimetic Control Center, RIKEN, April 2004-March 2008
Assistant Professor, Nagoya University, February 2000-March 2005
Postdoctoral Fellow (JSPS), Nagoya University, October 1999-January 2000
Research Associate (JSPS, DC1), Nagoya University, April 1997-October 1999

Field of Interest
Biology: Chronobiology, Molecular biology, Cellular biology, Circadian rhythms, Morphogenesis, Microbiology;
Arts and Humanity studies: Bioart, Bioaesthetics, History and philosophy of biology, Ethical Legal Societal Issues of biological science and technology (ELSI), History of arts

Published Articles
Iwasaki H. (2020) "Culturing <Paper>cut" Performance Research 25(3) 72 - 73 Apr 2, 2020
Shiryu Kirie, Hideo Iwasaki, Koji Noshita, Hiroyoshi Iwata (2020) "A theoretical morphological model for quantitative description of the three-dimensional floral morphology in water lily (Nymphaea)" PLOS ONE 15(10) e0239781 - e0239781
Koji Kawasaki, Hideo Iwasaki (2020) "Involvement of glycogen metabolism in circadian control of UV resistance in cyanobacteriaPLOS Genetics 16(11) e1009230 - e1009230 Nov 30, 2020
Kawamoto N, Ito H, Tokuda IT, and Hideo Iwasaki (2020) "Damped circadian oscillation in the absence of KaiA in Synechococcus" Nature Communications, 11, 2242. doi: 10.1038/s41467-020-16087-x
Yoriko Murayama, Hiroshi Koric, Chiaki Oshima, Takao Kondo, Hideo Iwasaki, and Hiroshi Itoh (2017) “Low temperature nullifies the circadian clock in cyanobacteria through Hopf bifurcation” Proc. Natl. Acad. Sci. USA, 2017 Apr 19. doi: 10.1073/pnas.1620378114
Takano S, Tomita J, Sonoike K, H. Iwasaki* (2015) "The initiation of nocturnal dormancy in Synechococcus as an active process." BMC Biol. 2015 Jun 10;13:36. doi: 10.1186/s12915-015-0144-2.
Ishihara J, Tachikawa M, H. Iwasaki, Mochizuki A. (2015) "Mathematical study of pattern formation accompanied by heterocyst differentiation in multicellular cyanobacterium." J Theor Biol. 2015 Apr 21;371:9-23. doi: 10.1016/j.jtbi.2015.01.034. Epub 2015 Feb 7.
Umetani M, Hosokawa N, Kitayama Y, H. Iwasaki* (2014) "Hypersensitive photic responses and intact genome-wide transcriptional control without the KaiC phosphorylation cycle in the Synechococcus circadian system." J. Bacteriol.2014 Feb;196(3):548-55. doi: 10.1128/JB.00892-13. Epub 2013 Nov 15.
Castro, JM, Iwasaki H (2014) “Heliotropika: Interfacing between humans and cyanobacteria” International Journal of Arts and Technology 7(4):373 DOI: 10.1504/IJART.2014.066455
Xu Y, Weyman PD, Umetani M, Xiong J, Qin X, Xu Q, H. Iwasaki, Johnson CH. (2013) "Circadian yin-yang regulation and its manipulation to globally reprogram gene expression." Curr Biol..2013 Dec 2;23(23):2365-74. doi: 10.1016/j.cub.2013.10.011. Epub 2013 Nov 7.
N. Hosokawa, H. Kushige and H. Iwasaki* (2013) "Attenuation of the posttranslational oscillator via transcription?translation feedback enhances circadian-phase shifts in Synechococcus"  Proc. Natl. Acad. Sci. USA, Aug 27;110(35):14486-91. doi: 10.1073/pnas.1302243110. Epub 2013 Aug 12.
Kushige, H., Kugenuma, H., Matsuoka, M., Ehira, S., Ohmori, M., Iwasaki, H.* (2013) "Genome-wide and heterocyst-specific circadian gene expression in the filamentous cyanobacterium, Anabaena sp. PCC 7120". J. Bacteriol. 195: 1276-1284
M. Hanaoka*, N. Takai, N. Hosokawa, M. Fujiwara, Y. Akimoto, N. Kobori, H. Iwasaki, T. Kondo, K. Tanaka (2012) "RpaB, another response regulator operating circadian clock-dependent transcriptional regulation in Synechococcus elongatus PCC 7942" J. Biol. Chem., 287: 26321-26327
N. Hosokawa, T. Hatakeyama, T. Kojima, Y. Kikuchi, H. Ito and H. Iwasaki* (2011) "Circadian transcriptional regulation by the posttranslational oscillator without de novo clock gene expression in Synechococcus" Proc. Natl. Acad. Sci. USA, 108: 15396-15401.
H. Asai, S. Iwamori, K. Kawai, S. Ehira, J. Ishihara, K. Aihara, S. Shoji, H. Iwasaki* (2009) "Cyanobacterial cell lineage analysis of the spatiotemporal hetR expression profile during heterocyst pattern formation in Anabaena sp. PCC 7120" PLoS ONE, 4(10): e7371 (October 12, 2009)
H. Ito, M. Mutsuda, Y. Murayama, J. Tomita, N. Hosokawa, K. Terauchi, C. Sugita, M. Sugita, T. Kondo, H. Iwasaki* (2009) "Cyanobacterial daily life with Kai-based circadian and diurnal genome-wide transcriptional control in Synechococcus elongatus" Proc. Natl. Acad. Sci. USA, 106:14168-14173 (June 30, 2009)
H. Tozaki, T. Kobe, K. Aihara, H. Iwasaki* (2008) "An attempt to reveal a role of a transcription/translation feedback loop in the cyanobacterial KaiC protein-based circadian system by using a semi-synthetic method" Int. J. Bioinform. Res. Appl. , 4: 435-444
S.R. Mackey, JS. Cho, Y. Kitayama, H. Iwasaki, G. Dong, S.S. Golden (2008) "Proteins found in a CikA-interaction assay link the circadian clock, metabolism, and cell division in Synechococcus elongatus" J. Bacteriol., 190: 3738-3746
A. Seki, M. Hanaoka, Y. Akimoto, S. Masuda, H. Iwasaki, K. Tanaka (2007) "Induction of a group 2 sigma factor, RpoD3, by high light and the underlying mechanism in Synechococcus elongatus PCC 7942" J. Biol. Chem., 282: 36887-36894
F. Miyoshi, Y. Nakayama , K. Kaizu, H. Iwasaki, M. Tomita (2007) "A mathematical model for the Kai-protein-based chemical oscillator and clock gene expression rhythms in cyanobacteria" J. Biol. Rhythms, 22: 69-80
N. Takai, M. Nakajima, T. Oyama, R. Kito, C. Sugita, M. Sugita, T. Kondo, H. Iwasaki* (2006) "A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria " Proc Natl Acad Sci USA, 103: 12109-12114
H. Kageyama, T. Nishiwaki, M. Nakajima, H. Iwasaki, T. Oyama, T. Kondo (2006) "Cyanobacterial circadian pacemaker: Kai protein complex dynamics in the KaiC phosphorylation cycle in vitro" Molecular Cell, 23: 161-171
M. Nakajima, K. Imai, H. Ito, T. Nishiwaki, Y. Murayama, H. Iwasaki, T. Oyama, T. Kondo (2005) "Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro" Science 308, 5720: 414-415
Tomita J, Nakajima M, Kondo T, Iwasaki H* (2005) "No transcription-translation feedback in circadian rhythm of KaiC phosphorylation." Science 307, 5707: 251-254
T. Nishiwaki, Satomi Y, Nakajima M, Lee C, Kiyohara R, Kageyama H, Kitayama Y, Temamoto M, Yamaguchi A, Hijikata A, Go M, Iwasaki H, Takao T, Kondo T. (2004) "Role of KaiC phosphorylation in the circadian clock system of Synechococcus elongatus PCC 7942." Proc Natl Acad Sci USA 101:13927-32
Imai K, Nishiwaki T, Kondo T, Iwasaki H* (2004) "Circadian rhythms in the synthesis and degradation of a master clock protein KaiC in cyanobacteria."  J Biol Chem 279:36534-9
Nakahira Y, Katayama M, Miyashita H, Kutsuna S, Iwasaki H, Oyama T, Kondo T (2004) "Global gene repression by KaiC as a master process of prokaryotic circadian system." Proc Natl Acad Sci USA 101: 881-885
Kitayama Y, Iwasaki H, Nishiwaki T, Kondo T (2003) "KaiB functions as an attenuator of KaiC phosphorylation in the cyanobacterial circadian clock system." EMBO J.22:2127-34
Kageyama H, Kondo T, Iwasaki H* (2003) "Circadian formation of clock protein complexes by KaiA, KaiB, KaiC, and SasA in cyanobacteria." J Biol Chem.278:2388-95
Iwasaki H*, Nishiwaki T, Kitayama Y, Nakajima M, Kondo T (2002) *corresponding author "KaiA-stimulated KaiC phosphorylation in circadian timing loops in cyanobacteria." Proc Natl Acad Sci USA 99:15788-93
Taniguchi Y, Yamaguchi A, Hijikata A, Iwasaki H, Kamagata K, Ishiura M, Go M, Kondo T (2001) "Two KaiA-binding domains of cyanobacterial circadian clock protein KaiC." FEBS lett.496: 86-90
Iwasaki H, Williams SB, Kitayama Y, Ishiura M, Golden SS, Kondo T (2000) "A KaiC-interacting sensory histidine kinase, SasA, necessary to sustain robust circadian oscillation in cyanobacteria." Cell 101: 223-233
Nishiwaki T, Iwasaki H, Ishiura M, Kondo T (2000) "Nucleotide binding and autophosphorylation of the clock protein KaiC as a circadian timing process of cyanobacteria." Proc Natl Acad Sci USA 97: 495-499
S Hirota, K Hayamizu, T Okuno, M Kishi, H Iwasaki, T Kondo, T Hibino, T Takabe, T Kohzuma, O Yamauchi (2000) "Spectroscopic and electrochemical studies on structural change of plastocyanin and its tyrosine 83 mutants induced by interaction with lysine peptides" Biochemistry, 39: 6357-6364
Iwasaki H, Taniguchi Y, Ishiura M, Kondo T (1999) "Physical interactions among circadian clock proteins, KaiA, KaiB and KaiC, in cyanobacteria." EMBO J 18: 1137-1145
NJ Cosper, C Stalhandske, H Iwasaki, T Oshima, R Scott, T Iwasaki (1999) "Structural conservation of the isolated zinc site in archaeal zinc-containing ferredoxins as revealed by X-ray absorption spectroscopic analysis and its evolutionary implications." J. Biol. Chem.274: 23160-23168
Ishiura, M, Kutsuna S, Aoki S, Iwasaki H, Andersson CR, Tanabe A, Golden SS, Johnson CH, Kondo T (1998) "Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria." Science 281: 1519-1523
M Takahashi, H. Iwasaki, T. Niimi, O Yamashita, T Yaginuma (1998) "Changing profiles of mRNA levels of Cdc2 and a novel Cdc2-related kinase (Bcdrk) in relation to ovarian development and embryonic diapause of Bombyx mori." Appl. Entomol. Zool. 33: 551-559
H Iwasaki, M Takahashi, T Niimi, O Yamashita, T Yaginuma (1996) "Cloning of cDNAs encoding Bombyx homologues of Cdc2 and Cdc2-related kinase from eggs." Insect Mol. Biol.6: 131-141
Invited Review Articles & Chapters
Iwasaki H (2009) "A posttranslational chemical circadian oscillator in cyanobacteria" Systems Biology: The Challenge of Complexity (Eds. Nakanishi,S., Kageyama,R., Watanabe,D), Springer
Iwasaki H (2009) "Factors involved in transcriptional output from the Kai-protein-based circadian oscillator" Bacterial Circadian Programs (Eds. J. Ditty, S. Mackey, C.H. Johnson), Springer
Iwasaki H, Kondo T. (2004) "Circadian timing mechanism in the prokaryotic clock system of cyanobacteria." J. Biol. Rhythms 19: 436-444
Iwasaki H, Kondo T. (2002) "Histidine kinases in the cyanobacterial circadian system" Histidine Kinases (Eds. M. Inouye and R. Dutta), Academic Press
Iwasaki H, Kondo T (2000) "The current state and problems of circadian clock studies in cyanobacteria." Plant Cell Physiol 41: 1013-1020
Iwasaki H, Dunlap JC (2000) "Microbial circadian oscillatory systems in Neurospora and Synechococcus: models for cellular clocks." Curr. Opin. Microbiology 3: 189-19

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